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Daria Mochly-Rosen Selected Research

Aldehyde Dehydrogenase

12/2019Aldehyde dehydrogenase 2 activity and aldehydic load contribute to neuroinflammation and Alzheimer's disease related pathology.
12/2018ALDH1 Bio-activates Nifuroxazide to Eradicate ALDHHigh Melanoma-Initiating Cells.
12/2018Aldehyde dehydrogenase 3A1 activation prevents radiation-induced xerostomia by protecting salivary stem cells from toxic aldehydes.
8/2017Targeting aldehyde dehydrogenase activity in head and neck squamous cell carcinoma with a novel small molecule inhibitor.
12/2016The Role of Mitochondrial Aldehyde Dehydrogenase 2 (ALDH2) in Neuropathology and Neurodegeneration.
12/2016Genetic variations of aldehyde dehydrogenase 2 and alcohol dehydrogenase 1B are associated with the etiology of atrial fibrillation in Japanese.
1/2016In Vivo Post-Cardiac Arrest Myocardial Dysfunction Is Supported by Ca2+/Calmodulin-Dependent Protein Kinase II-Mediated Calcium Long-Term Potentiation and Mitigated by Alda-1, an Agonist of Aldehyde Dehydrogenase Type 2.
1/2016Aldehyde dehydrogenase 2 in aplastic anemia, Fanconi anemia and hematopoietic stem cells.
1/2015Aldehydic load and aldehyde dehydrogenase 2 profile during the progression of post-myocardial infarction cardiomyopathy: benefits of Alda-1.
1/2015Neuroprotective effects of aldehyde dehydrogenase 2 activation in rotenone-induced cellular and animal models of parkinsonism.
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Daria Mochly-Rosen Research Topics

Disease

29Ischemia
01/2016 - 06/2002
21Myocardial Infarction
02/2022 - 08/2006
18Neoplasms (Cancer)
10/2022 - 05/2002
16Reperfusion Injury
02/2022 - 08/2003
15Heart Failure
10/2019 - 10/2002
11Inflammation (Inflammations)
01/2022 - 10/2007
11Infarction (Infarctions)
10/2013 - 11/2003
10Mitochondrial Diseases (Mitochondrial Disease)
01/2022 - 11/2011
8Pain (Aches)
11/2021 - 05/2004
6Glucosephosphate Dehydrogenase Deficiency
01/2022 - 06/2016
6Hypertension (High Blood Pressure)
07/2012 - 10/2002
6Cardiomegaly (Heart Hypertrophy)
10/2011 - 10/2002
5Cardiovascular Diseases (Cardiovascular Disease)
01/2022 - 01/2012
5Flushing
01/2022 - 02/2010
5Huntington Disease (Huntington's Disease)
01/2018 - 12/2013
5Stroke (Strokes)
01/2017 - 07/2003
4Fibrosis (Cirrhosis)
03/2021 - 01/2008
4Heart Diseases (Heart Disease)
03/2015 - 01/2008
4Hypertrophy
10/2011 - 10/2002
4Brain Ischemia (Cerebral Ischemia)
12/2005 - 07/2003
3COVID-19
01/2022 - 01/2021
3Hemolytic Anemia
01/2022 - 10/2018
3Neurodegenerative Diseases (Neurodegenerative Disease)
01/2019 - 01/2014
3Myocardial Ischemia (Ischemic Heart Diseases)
09/2013 - 02/2007
3Coronary Artery Disease (Coronary Atherosclerosis)
05/2005 - 01/2004
2Carcinogenesis
02/2022 - 05/2002
2Communicable Diseases (Infectious Diseases)
01/2022 - 01/2021
2Atrial Fibrillation
01/2021 - 12/2016
2Brain Diseases (Brain Disorder)
01/2020 - 01/2011
2Sepsis (Septicemia)
01/2020 - 01/2019
2Alzheimer Disease (Alzheimer's Disease)
12/2019 - 12/2016
2Cardiomyopathies (Cardiomyopathy)
01/2019 - 01/2015
2Head and Neck Neoplasms (Head and Neck Cancer)
12/2018 - 08/2013
2Xerostomia
12/2018 - 08/2013
2Squamous Cell Carcinoma of Head and Neck
01/2018 - 08/2017
2Cardiotoxicity
01/2018 - 11/2011
2Diabetes Complications
01/2018 - 12/2012
2Parkinson Disease (Parkinson's Disease)
12/2016 - 02/2013
2Heart Arrest (Cardiac Arrest)
01/2016 - 06/2005
2Brain Injuries (Brain Injury)
06/2013 - 07/2003
2Angina Pectoris
01/2012 - 11/2011
2Prostatic Neoplasms (Prostate Cancer)
06/2011 - 08/2008
2Atherosclerosis
01/2010 - 01/2008
2Hyperglycemia
01/2009 - 10/2005
2Left Ventricular Hypertrophy (Ventricular Hypertrophy, Left)
12/2008 - 10/2002

Drug/Important Bio-Agent (IBA)

23Protein Kinase CIBA
10/2011 - 06/2002
20AldehydesIBA
10/2022 - 09/2008
20Proteins (Proteins, Gene)FDA Link
03/2021 - 05/2002
19Peptides (Polypeptides)IBA
02/2022 - 08/2003
17IsoenzymesIBA
09/2013 - 05/2002
16Aldehyde DehydrogenaseIBA
12/2019 - 02/2009
12EnzymesIBA
10/2022 - 07/2005
9Phosphotransferases (Kinase)IBA
02/2022 - 11/2003
7Ethanol (Ethyl Alcohol)IBA
12/2019 - 08/2005
6Pharmaceutical PreparationsIBA
10/2022 - 02/2008
6delta proteinIBA
02/2022 - 11/2003
6Glucosephosphate Dehydrogenase (Glucose 6 Phosphate Dehydrogenase)IBA
01/2022 - 06/2016
6Protein Kinases (Protein Kinase)IBA
06/2013 - 11/2004
6Protein Kinase C-epsilonIBA
10/2005 - 05/2002
5Amino AcidsFDA Link
02/2022 - 08/2006
54-hydroxy-2-nonenal (4-hydroxynonenal)IBA
11/2021 - 04/2010
5Glucose (Dextrose)FDA LinkGeneric
01/2018 - 07/2004
5SaltsIBA
12/2008 - 10/2002
4Oxidoreductases (Dehydrogenase)IBA
10/2022 - 07/2005
4AcetaldehydeIBA
02/2022 - 02/2010
4Oxygen (Dioxygen)IBA
06/2005 - 12/2003
3Protein Isoforms (Isoforms)IBA
10/2022 - 06/2002
3Protein Kinase C-deltaIBA
02/2022 - 08/2004
3VaccinesIBA
01/2022 - 01/2021
3Biomarkers (Surrogate Marker)IBA
01/2022 - 02/2008
3Adenosine Triphosphate (ATP)IBA
12/2018 - 10/2013
3Reactive Oxygen Species (Oxygen Radicals)IBA
01/2018 - 02/2013
3polyglutamineIBA
11/2016 - 01/2014
3Huntingtin ProteinIBA
11/2016 - 12/2013
3Neuroprotective AgentsIBA
01/2015 - 12/2005
3Mitochondrial Aldehyde DehydrogenaseIBA
09/2014 - 10/2010
3Protein Serine-Threonine Kinases (Protein-Serine-Threonine Kinase)IBA
01/2012 - 01/2008
2IgYIBA
01/2022 - 01/2021
2LipopolysaccharidesIBA
01/2021 - 01/2020
2Dynamins (Dynamin)IBA
01/2020 - 01/2019
2BilirubinIBA
10/2018 - 06/2016
2Cisplatin (Platino)FDA LinkGeneric
08/2017 - 05/2017
2Biological ProductsIBA
12/2016 - 06/2011
2CalciumIBA
01/2016 - 01/2016
2Glyceraldehyde-3-Phosphate Dehydrogenases (GAPD)IBA
10/2015 - 06/2013
2Therapeutic UsesIBA
01/2015 - 12/2008
2Analgesics (Analgesic Drugs)IBA
08/2014 - 01/2014
2Opioid Analgesics (Opioids)IBA
01/2014 - 07/2004
2BradykininIBA
09/2013 - 04/2009
2Nitroglycerin (Dynamite)FDA LinkGeneric
01/2012 - 11/2011
2Formaldehyde (Formol)FDA Link
08/2011 - 05/2004
2tat Gene Products (tat Protein)IBA
10/2010 - 08/2003
2Creatine Kinase (Creatine Phosphokinase)IBA
02/2009 - 08/2003
2Receptors for Activated C KinaseIBA
01/2009 - 10/2005
2dimemorfan (AT 17)IBA
06/2008 - 10/2002
2Cytochromes c (Cytochrome c)IBA
08/2007 - 06/2005

Therapy/Procedure

10Therapeutics
10/2022 - 01/2007
3Radiotherapy
12/2018 - 07/2012
2Intraperitoneal Injections
02/2009 - 05/2007
2Heart Transplantation (Grafting, Heart)
10/2007 - 09/2004